SIRE


DAM


OFFSPRING

Clear

x

Clear

>

100% clear

Clear

x

Carrier

>

50%  clear + 50% carriers

Clear

x

Affected

>

100% carriers

Carrier

x

Clear

>

50%  clear + 50% carriers

Carrier

x

Carrier

>

25% clear + 25% affected + 50% carriers

Carrier

x

Affected

>

50% carriers + 50% affected

Affected

x

Clear

>

100%  carriers

Affected

x

Carrier

>

50% carriers + 50% affected

Affected

x

Affected

>

100% affected

Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

Carrier Genotype: N / CNM [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)

Affected Genotype: CNM / CNM [ Homozygous mutant ] The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM) and will pass the mutant gene to its entire offspring