SIRE |
|
DAM |
|
OFFSPRING |
Clear |
x |
Clear |
> |
100% clear |
Clear |
x |
Carrier |
> |
50% clear + 50% carriers |
Clear |
x |
Affected |
> |
100% carriers |
Carrier |
x |
Clear |
> |
50% clear + 50% carriers |
Carrier |
x |
Carrier |
> |
25% clear + 25% affected + 50% carriers |
Carrier |
x |
Affected |
> |
50% carriers + 50% affected |
Affected |
x |
Clear |
> |
100% carriers |
Affected |
x |
Carrier |
> |
50% carriers + 50% affected |
Affected |
x |
Affected |
> |
100% affected |
Clear Genotype: N / N [ Homozygous normal ] The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Carrier Genotype: N / CNM [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Affected Genotype: CNM / CNM [ Homozygous mutant ] The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Hereditary Myopathy / Centronuclear Myopathy (HMLR, CNM) and will pass the mutant gene to its entire offspring